Automated Reactor Sampling (ARS) systems deliver precise, on-line sampling of bioreactor contents while ensuring complete, sanitary isolation. Through fully programmable cleaning procedures and state-of-the-art valve train design, Groton’s ARS systems will give you the tight control you need today. As it becomes increasingly important to maximize product yields, eliminate batch failures, and shorten product development cycles, Groton can also provide you with integrated systems and components for monitoring, measuring, and documenting your entire biotechnology process.

Automated, Precision Sampling. The ARS control system provides fully programmable, scheduled sampling of a bioreactor 24/7. A precision syringe pump system guarantees precision sample volumes and ensures maximum assay accuracy. The ARS eliminates labor intensive, error prone manual sampling processes now used typically in all facets of commercial biotechnology.

Sanitary Interface. Complete isolation of the reactor is provided by a dual isolated valve system. This feature, coupled with programmable cleaning and sterilization procedures, provides unmatched degrees of protection against reactor contamination.

Scaleable, Multiplexed Architecture. ARS systems are offered in process development and production configurations. Each version is optimized based on sample volume requirements. The ARS multiplex option provides automated sampling of up to four reactors. Users will benefit from this commonality when transitioning between process development and production environments.

CIP/SIP Compatible. The valve train is sanitized and sterilized via script driven cleaning cycles that are designed to correspond to customer SOPs. Large scale production ARS systems support SIP.

21CFR Part 11 Compliant. Secure data streams enable compliance with the FDA’s 21CFR Part 11 requirements. In addition, complete system validation packages have been developed to help customers meet cGMP standards and other FDA initiatives, such as the FDA’s Process Analytical Technologies (PAT) Initiative.

Modular, Flexible Design. The ARS System is designed to connect seamlessly to the GPA1000 Process Analyzer and can also be configured to interface your reactor with many process analyzers, a fraction collection system, and other analytical instruments.

Comprehensive System Support. Groton’s knowledgeable technical support engineers understand the ARS system and how it fits within an overall automation solution. Extensive user documentation is provided with every system based on GAMP4 guidelines.

Minimum Sample Dead Volume (Typical)

Sample Wetted Surfaces

Sample Tubing Specification

Reactor Connection

Valve Actuators

Valve Control

Cleaning Systems (CIP) Fully automated for development and production models. Cleaning chemistry to conform to customer specification. Sodium hydroxide, hypochlorite, or standard detergents compatible.

Reagent Consumption per Cleaning Cycle (Typical)

Sterilization Systems

Reagent Consumption per Sterilization Cycle for Chemical Sterilization Processes (Typical)

Control System